Jorma Isola Selected Research

Breast Neoplasms (Breast Cancer)

6/2022	MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels.
1/2022	Outcome and Biomarker Supervised Deep Learning for Survival Prediction in Two Multicenter Breast Cancer Series.
1/2021	Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy.
1/2020	Fluoro-Chromogenic Labelling for Detection of MCM2 to Assess Proliferation Activity in HER2-amplified Breast Carcinomas.
1/2020	ARX788, a novel anti-HER2 antibody-drug conjugate, shows anti-tumor effects in preclinical models of trastuzumab emtansine-resistant HER2-positive breast cancer and gastric cancer.
10/2019	A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine.
10/2018	Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
3/2018	Comparison of Antibodies for Immunohistochemistry-based Detection of HER3 in Breast Cancer.
7/2016	Cyclin E amplification, over-expression, and relapse-free survival in HER-2-positive primary breast cancer.
1/2016	Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.

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Jorma Isola Research Topics

Disease

73	Neoplasms (Cancer) 01/2021 - 02/2002
60	Breast Neoplasms (Breast Cancer) 06/2022 - 02/2002
8	Carcinoma (Carcinomatosis) 10/2018 - 01/2004
7	Neoplasm Metastasis (Metastasis) 05/2014 - 02/2002
6	Celiac Disease (Celiac Sprue) 12/2021 - 01/2021
4	Carcinogenesis 01/2013 - 02/2002
3	Stomach Neoplasms (Stomach Cancer) 01/2020 - 07/2011
3	Ovarian Neoplasms (Ovarian Cancer) 05/2015 - 08/2006
3	Prostatic Neoplasms (Prostate Cancer) 07/2012 - 02/2009
3	Aneuploidy (Aneuploid) 01/2011 - 03/2003
2	Atrophy 02/2021 - 12/2019
2	Endometrial Neoplasms (Endometrial Cancer) 10/2016 - 05/2014
2	Squamous Cell Carcinoma of Head and Neck 06/2010 - 01/2002
2	Heart Failure 12/2009 - 02/2006
2	Neuroblastoma 02/2009 - 12/2005
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2004 - 08/2002
2	Leiomyoma (Uterine Fibroids) 01/2004 - 08/2002
1	Eccrine Porocarcinoma 01/2022
1	Injection Site Reaction 12/2019
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 12/2019
1	Triple Negative Breast Neoplasms 10/2018
1	Endometrioid Carcinoma 10/2016

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 02/2021 - 01/2002
18	Trastuzumab (Herceptin)FDA Link 01/2021 - 01/2004
12	Estrogen ReceptorsIBA 01/2022 - 11/2002
11	Hormones (Hormone)IBA 01/2020 - 02/2002
9	Messenger RNA (mRNA)IBA 01/2016 - 01/2002
9	ErbB Receptors (EGF Receptor)IBA 09/2011 - 11/2002
9	Progesterone Receptors (Progesterone Receptor)IBA 09/2011 - 11/2002
8	ParaffinIBA 12/2021 - 07/2004
8	Biological ProductsIBA 01/2016 - 09/2004
7	Ado-Trastuzumab EmtansineIBA 01/2020 - 01/2011
6	Formaldehyde (Formol)FDA Link 12/2021 - 07/2004
6	Immunoconjugates (Immunoconjugate)IBA 01/2020 - 01/2011
6	Keratins (Keratin)IBA 01/2020 - 11/2002
6	DNA (Deoxyribonucleic Acid)IBA 01/2011 - 03/2003
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2006
5	Pharmaceutical PreparationsIBA 01/2018 - 12/2004
5	Phenobarbital (Luminal)FDA Link 01/2016 - 10/2005
4	Keratin-5 (Keratin 5)IBA 10/2018 - 11/2002
4	Phosphotransferases (Kinase)IBA 01/2016 - 01/2006
4	AnthracyclinesIBA 11/2011 - 05/2002
4	Epirubicin (Ellence)FDA LinkGeneric 12/2009 - 05/2002
4	Fluorouracil (Carac)FDA LinkGeneric 12/2009 - 05/2002
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2009 - 05/2002
4	Monoclonal AntibodiesIBA 02/2008 - 01/2004
4	Protein Isoforms (Isoforms)IBA 10/2007 - 11/2003
3	Hematoxylin (Haematoxylon)IBA 01/2022 - 11/2011
3	Eosine Yellowish-(YS) (Eosin)IBA 01/2022 - 11/2011
3	Glutens (Glutelin)IBA 01/2021 - 12/2019
3	AntibodiesIBA 03/2018 - 11/2002
3	Gefitinib (Iressa)FDA Link 01/2016 - 06/2010
3	Docetaxel (Taxotere)FDA Link 01/2016 - 02/2006
3	Vinorelbine (Navelbine)FDA LinkGeneric 01/2016 - 02/2006
3	Estrogen Receptor alphaIBA 01/2015 - 02/2005
3	Estrogens (Estrogen)FDA Link 10/2006 - 02/2005
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 06/2005 - 02/2002
2	Cyclin EIBA 01/2020 - 07/2016
2	PolymersIBA 01/2020 - 10/2005
2	resazurinIBA 01/2018 - 04/2011
2	Membrane Proteins (Integral Membrane Proteins)IBA 04/2015 - 05/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2014 - 06/2010
2	LigandsIBA 01/2013 - 01/2006
2	Androgen Receptors (Androgen Receptor)IBA 07/2012 - 10/2006
2	NestinIBA 09/2011 - 12/2005
2	Lapatinib (GW572016)FDA Link 04/2011 - 08/2010
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 05/2010 - 12/2006
2	human ERBB2 proteinIBA 12/2009 - 03/2003
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 08/2009 - 05/2007
2	Tamoxifen FDA LinkGeneric 05/2008 - 04/2007
2	Complementary DNA (cDNA)IBA 01/2007 - 03/2003
2	Peptide Hydrolases (Proteases)FDA Link 01/2006 - 02/2005
2	Fumarate Hydratase (Fumarase)IBA 01/2004 - 08/2002
2	trioctyl phosphine oxide (TOPO)IBA 08/2003 - 05/2002
1	Transforming Growth Factor-beta Type II ReceptorIBA 06/2022
1	IntegrinsIBA 06/2022
1	erucylphosphocholineIBA 01/2022
1	Transferrin Receptors (Transferrin Receptor)IBA 02/2021
1	Cytochromes b (Cytochrome b)IBA 02/2021
1	AutoantibodiesIBA 02/2021
1	IronIBA 02/2021
1	metal transporting protein 1 (ferroportin)IBA 02/2021
1	MetalsIBA 02/2021
1	Peptides (Polypeptides)IBA 01/2021
1	Glutamine (L-Glutamine)FDA Link 01/2021
1	apolipoprotein A-IV (apolipoprotein AIV)IBA 01/2021
1	Protein Glutamine gamma Glutamyltransferase 2IBA 01/2021
1	ZED1227IBA 01/2021
1	ARX788IBA 01/2020
1	AMG-714IBA 12/2019
1	XMT-1522IBA 10/2019
1	CaspasesIBA 01/2018
1	Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)IBA 10/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2016
1	pegylated 17-hydroxywortmanninIBA 01/2016

Therapy/Procedure

22	Therapeutics 01/2021 - 05/2002
4	Drug Therapy (Chemotherapy) 11/2011 - 06/2006
2	Salpingo-oophorectomy 05/2015 - 05/2014
2	Radiotherapy 09/2010 - 06/2010
1	Gluten-Free Diet 01/2021